The Nature Index (NI) journal ACS NANO (IF = 13.709) has published the latest result of the study of aging-associated insulin resistance by the team of Prof. Luo Xianghang, Director of Endocrine Research Center of Xiangya Hospital, Central South University. The study has revealed the crucial role of bone marrow mesenchymal stem cells (BM-MSC)–derived exosomal miR-29b-3p in controlling the aging-associated insulin resistance provided a new approach for the clarification of the pathogenesis the prevention strategy of type 2 diabetes as well as a new potential drug target.
Along with rapid economic development, population aging lifestyle changes, a spiking incidence of metabolic disorders such as type 2 diabetes has become one of the most concerned public health issues across the world. Insulin resistance is present throughout the type 2 diabetes improving insulin resistance plays an important role in guiding clinically effective intervention for abnormal glucose metabolism. However, the specific development mechanism of insulin resistance, especially aging-associated insulin resistance, is not well established.
The online paper by Prof. Luo Xianghang’s team is entitled "Bone Marrow Mesenchymal Stem Cells-Derived Exosomal MiR-29b-3p Regulates Aging-Associated Insulin Resistance". Associate research fellows Su Tian Xiao Yuzhong are the first authors; Prof. Luo Xianghang is the corresponding author; Xiangya Hospital of Central South University is the organization of the first corresponding authors.
Prof. Luo Xianghang’s team has been dedicated to the pathogenesis prevention of metabolic disorders including osteoporosis, type 2 diabetes, obesity. In recent years, the team has made many important progresses in its research is expected to bring new insights to the prevention treatment of osteoporosis type 2 diabetes.
Link to article: https://pubs.acs.org.ccindex.cn/doi/10.1021/acsnano.8b09375
